Pro-epidermal growth factor

Definition:

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro.

References:

[1]. P M Hermann, et al. Neurotrophic actions of a novel molluscan epidermal growth factor. J Neurosci. 2000 Sep 1;20(17):6355-64. [Content Brief]

[2]. Wouter M Tiel Groenestege, et al. Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest. 2007 Aug;117(8):2260-7. [Content Brief]

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