Pro-thyrotropin-releasing hormone

Definition:

As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.

References:

[1]. Erzsébet Gáspár, et al. Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. FASEB J. 2010 Feb;24(2):393-403. [Content Brief]

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