Probable methyltransferase TARBP1

Definition:

Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs.; (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA.

References:

[1]. Hong Wu, et al. Crystal structure of the methyltransferase domain of human TARBP1. Proteins. 2008 Jul;72(1):519-25. [Content Brief]

[2]. F Wu-Baer, et al. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA. EMBO J. 1995 Dec 1;14(23):5995-6009. [Content Brief]

[3]. F Wu-Baer, et al. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J Biol Chem. 1996 Feb 23;271(8):4201-8. [Content Brief]

[4]. F Wu-Baer, et al. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7153-7. [Content Brief]

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