Properdin

Definition:

A positive regulator of the alternate pathway (AP) of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).

References:

[1]. Dennis V Pedersen, et al. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol. 2019 Aug 22;10:2007. [Content Brief]

[2]. Dennis V Pedersen, et al. Functional and structural insight into properdin control of complement alternative pathway amplification. EMBO J. 2017 Apr 13;36(8):1084-1099. [Content Brief]

[3]. Viviana P Ferreira, et al. Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology. 2010 Nov;215(11):932-40. [Content Brief]

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