Prostaglandin E synthase 2

Definition:

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity).

References:

[1]. Kikuko Watanabe, et al. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. Biochem Biophys Res Commun. 2003 Jun 27;306(2):577-81. [Content Brief]

[2]. Taro Yamada, et al. PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme. Biochemistry. 2007 Jul 17;46(28):8414-24. [Content Brief]

[3]. Kikuko Watanabe, et al. Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Biochem Biophys Res Commun. 2008 Mar 21;367(4):782-6. [Content Brief]

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