Protein arginine methyltransferase NDUFAF7, mitochondrial

Definition:

Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex.

References:

[1]. Virginie F Rhein, et al. NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I. J Biol Chem. 2013 Nov 15;288(46):33016-26. [Content Brief]

[2]. Sergio Carilla-Latorre, et al. MidA is a putative methyltransferase that is required for mitochondrial complex I function. J Cell Sci. 2010 May 15;123(Pt 10):1674-83. [Content Brief]

[3]. Olga Zurita Rendón, et al. The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis. Hum Mol Genet. 2014 Oct 1;23(19):5159-70. [Content Brief]

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