Protein ARV1

Definition:

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.

References:

[1]. A H Tinkelenberg, et al. Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. J Biol Chem. 2000 Dec 29;275(52):40667-70. [Content Brief]

[2]. Evelyn Swain, et al. Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem. 2002 Sep 27;277(39):36152-60. [Content Brief]

[3]. Fumin Tong, et al. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J Biol Chem. 2010 Oct 29;285(44):33632-41. [Content Brief]

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