Protein ecdysoneless homolog

Definition:

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

References:

[1]. Jun Hyun Kim, et al. Role of mammalian Ecdysoneless in cell cycle regulation. J Biol Chem. 2009 Sep 25;284(39):26402-10. [Content Brief]

[2]. Hyun-Woo Suh, et al. TXNIP interacts with hEcd to increase p53 stability and activity. Biochem Biophys Res Commun. 2013 Aug 23;438(2):264-9. [Content Brief]

[3]. Jun Hyun Kim, et al. Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation. Biol Chem. 2010 Jan;391(1):9-19. [Content Brief]

[4]. Ann-Katrin Claudius, et al. Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. PLoS Genet. 2014 Apr 10;10(4):e1004287. [Content Brief]

[5]. Ying Zhang, et al. The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function. Cancer Res. 2006 Jul 15;66(14):7167-75. [Content Brief]

[6]. T Sato, et al. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae. Mol Gen Genet. 1999 Jan;260(6):535-40. [Content Brief]

[7]. Riyaz A Mir, et al. A Novel Interaction of Ecdysoneless (ECD) Protein with R2TP Complex Component RUVBL1 Is Required for the Functional Role of ECD in Cell Cycle Progression. Mol Cell Biol. 2015 Dec 28;36(6):886-99. [Content Brief]

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