Protein EFR3 homolog A

Definition:

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.

References:

[1]. Jeeyun Chung, et al. Plasticity of PI4KIIIα interactions at the plasma membrane. EMBO Rep. 2015 Mar;16(3):312-20. [Content Brief]

[2]. Jeremy M Baskin, et al. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 2016 Jan;18(1):132-8. [Content Brief]

[3]. Fubito Nakatsu, et al. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. J Cell Biol. 2012 Dec 10;199(6):1003-16. [Content Brief]

[4]. Naveen Bojjireddy, et al. EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors. J Cell Sci. 2015 Jan 1;128(1):118-28. [Content Brief]

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