Protein Hook homolog 2

Definition:

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.

References:

[1]. Györgyi Szebenyi, et al. Hook2 contributes to aggresome formation. BMC Cell Biol. 2007 May 31;8:19. [Content Brief]

[2]. Györgyi Szebenyi, et al. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Traffic. 2007 Jan;8(1):32-46. [Content Brief]

[3]. Rafael Mattera, et al. The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A. Mol Biol Cell. 2020 Apr 15;31(9):963-979. [Content Brief]

[4]. Lai Xu, et al. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell. 2008 Dec;19(12):5059-71. [Content Brief]

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