Protein MIS12 homolog

Definition:

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments.

References:

[1]. Susan L Kline, et al. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol. 2006 Apr 10;173(1):9-17. [Content Brief]

[2]. Roshan L Shrestha, et al. Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol. 2013 Aug 19;23(16):1514-26. [Content Brief]

[3]. Chikashi Obuse, et al. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. Nat Cell Biol. 2004 Nov;6(11):1135-41. [Content Brief]

[4]. Gohta Goshima, et al. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J Cell Biol. 2003 Jan 6;160(1):25-39. [Content Brief]

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