Proteolysis targeting chimera (PROTAC)

Definition:

Proteolysis targeting chimera (PROTAC) is a kind of bifunctional small molecule, in which the target protein ligand and the E3 ubiquitin ligases (E3) ubiquitin ligase ligand are linked together through a linker to form a triplet compound.

References:

[1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 Jun 10;64(11):7839-7852. [Content Brief]

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