Pseudofolliculitis barbae

Definition:

Pseudofolliculitis barbae is a common skin disorder occurring predominantly in males of African origin, characterized by acneiform papules and pustules that result in keloidal scarring localized to the facial and submental regions. It is caused when highly curved hair shafts repenetrate the skin. A single nucleotide polymorphism in KRT75, which leads to a disruptive Ala12Thr substitution, has been demonstrated in the disease.

References:

[1]. Frederick N Quarles, et al. Pseudofolliculitis barbae. Dermatol Ther. 2007 May-Jun;20(3):133-6. [Content Brief]

[2]. Hermelita Winter, et al. An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. J Invest Dermatol. 2004 Mar;122(3):652-7. [Content Brief]

[3]. Sharon Bridgeman-Shah, et al. The medical and surgical therapy of pseudofolliculitis barbae. Dermatol Ther. 2004;17(2):158-63. [Content Brief]

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