Pyrroline-5-carboxylate reductase 3

Definition:

Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.

References:

[1]. Jessica De Ingeniis, et al. Functional specialization in proline biosynthesis of melanoma. PLoS One. 2012;7(9):e45190. [Content Brief]

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