Regulator of chromosome condensation

Definition:

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.

References:

[1]. David Halpin, et al. Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts. PLoS Biol. 2011 Dec;9(12):e1001225. [Content Brief]

[2]. F R Bischoff, et al. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature. 1991 Nov 7;354(6348):80-2. [Content Brief]

[3]. William Moore, et al. Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells. Curr Biol. 2002 Aug 20;12(16):1442-7. [Content Brief]

[4]. Yi Hao, et al. Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1. J Cell Biol. 2008 Sep 8;182(5):827-36. [Content Brief]

[5]. Christine E Schaner Tooley, et al. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature. 2010 Aug 26;466(7310):1125-8. [Content Brief]

[6]. L Renault, et al. Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell. 2001 Apr 20;105(2):245-55. [Content Brief]

[7]. Ting Chen, et al. N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol. 2007 May;9(5):596-603. [Content Brief]

[8]. M Ohtsubo, et al. Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Genes Dev. 1987 Aug;1(6):585-93. [Content Brief]

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