T-cell leukemia/lymphoma protein 1A

Definition:

Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

References:

[1]. J Laine, et al. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell. 2000 Aug;6(2):395-407. [Content Brief]

[2]. Y Pekarsky, et al. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3028-33. [Content Brief]

[3]. Jarmo Laine, et al. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J Biol Chem. 2002 Feb 1;277(5):3743-51. [Content Brief]

[4]. Gerald Künstle, et al. Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1. Mol Cell Biol. 2002 Mar;22(5):1513-25. [Content Brief]

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