T-lymphocyte activation antigen CD80

Definition:

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.; (Microbial infection) Acts as a receptor for adenovirus subgroup B.

References:

[1]. K Vandenborre, et al. Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. Immunology. 1999 Nov;98(3):413-21. [Content Brief]

[2]. Joshua J Short, et al. Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. Virus Res. 2006 Dec;122(1-2):144-53. [Content Brief]

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