TATA box-binding protein-associated factor RNA polymerase I subunit D

Definition:

Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

References:

[1]. Julia J Gorski, et al. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. EMBO J. 2007 Mar 21;26(6):1560-8. [Content Brief]

[2]. J Karsten Friedrich, et al. TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. J Biol Chem. 2005 Aug 19;280(33):29551-8. [Content Brief]

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