TATA box-binding protein-like 1

Definition:

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

References:

[1]. Yuan-Liang Wang, et al. TRF2, but not TBP, mediates the transcription of ribosomal protein genes. Genes Dev. 2014 Jul 15;28(14):1550-5. [Content Brief]

[2]. T Ohbayashi, et al. Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein. Biochem Biophys Res Commun. 1999 Feb 5;255(1):137-42. [Content Brief]

[3]. M D Rabenstein, et al. TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4791-6. [Content Brief]

[4]. Jayhong A Chong, et al. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr;25(7):2632-43. [Content Brief]

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