Testis-specific Y-encoded-like protein 5

Definition:

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7.

References:

[1]. Mirjam T Epping, et al. TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol. 2011 Jan;13(1):102-8. [Content Brief]

[2]. Eun Jin Kim, et al. TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. Biochem Biophys Res Commun. 2010 Feb 12;392(3):448-53. [Content Brief]

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