Thyroid receptor-interacting protein 6

Definition:

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.

References:

[1]. Eric Chastre, et al. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J. 2009 Mar;23(3):916-28. [Content Brief]

[2]. M Carmen Solaz-Fuster, et al. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal. 2006 Oct;18(10):1702-12. [Content Brief]

[3]. Jun Xu, et al. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. J Biol Chem. 2004 Mar 12;279(11):10459-68. [Content Brief]

[4]. Olivier Kassel, et al. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters. Genes Dev. 2004 Oct 15;18(20):2518-28. [Content Brief]

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