TIMELESS-interacting protein

Definition:

Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

References:

[1]. Yasemin Baris, et al. Fast and efficient DNA replication with purified human proteins. Nature. 2022 Jun;606(7912):204-210. [Content Brief]

[2]. Won-Ho Cho, et al. Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2523-7. [Content Brief]

[3]. Keziban Unsal-Kaçmaz, et al. The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Mol Cell Biol. 2007 Apr;27(8):3131-42. [Content Brief]

[4]. Danny M Chou, et al. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18143-7. [Content Brief]

[5]. Naoko Yoshizawa-Sugata, et al. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. J Biol Chem. 2007 Jan 26;282(4):2729-40. [Content Brief]

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