Transcription factor HES-1

Definition:

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

References:

[1]. Cédric S Tremblay, et al. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 2008 Sep 1;112(5):2062-70. [Content Brief]

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