Transcription factor MafA

Definition:

Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence.

References:

[1]. Donato Iacovazzo, et al. MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1027-1032. [Content Brief]

[2]. Martin Olbrot, et al. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6737-42. [Content Brief]

[3]. Shinsaku Aramata, et al. Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1. Biochim Biophys Acta. 2005 Jul 25;1730(1):41-6. [Content Brief]

[4]. Xun Lu, et al. A novel DNA binding mechanism for maf basic region-leucine zipper factors inferred from a MafA-DNA complex structure and binding specificities. Biochemistry. 2012 Dec 4;51(48):9706-17. [Content Brief]

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