Transient bullous dermolysis of the newborn

Definition:

Transient bullous dermolysis of the newborn is a rare disorder in which subepidermal blistering presents at birth. Tissue separation occurs below the lamina densa, due to abnormal intraepidermal accumulation of type VII collagen. The disease usually regresses during early life, as type VII collagen secretion gradually recovers.

References:

[1]. A M Christiano, et al. Genetic basis of dominantly inherited transient bullous dermolysis of the newborn: a splice site mutation in the type VII collagen gene. J Invest Dermatol. 1997 Dec;109(6):811-4. [Content Brief]

[2]. H Fassihi, et al. Transient bullous dermolysis of the newborn in three generations. Br J Dermatol. 2005 Nov;153(5):1058-63. [Content Brief]

[3]. N Hammami-Hauasli, et al. Transient bullous dermolysis of the newborn associated with compound heterozygosity for recessive and dominant COL7A1 mutations. J Invest Dermatol. 1998 Dec;111(6):1214-9. [Content Brief]

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