Transmembrane protein 181

Definition:

Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

References:

[1]. Jan E Carette, et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science. 2009 Nov 27;326(5957):1231-5. [Content Brief]

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