Tumor necrosis factor receptor superfamily member 25

Definition:

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.

References:

[1]. A M Chinnaiyan, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science. 1996 Nov 8;274(5289):990-2. [Content Brief]

[2]. J L Bodmer, et al. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity. 1997 Jan;6(1):79-88. [Content Brief]

[3]. S A Marsters, et al. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B. Curr Biol. 1996 Dec 1;6(12):1669-76. [Content Brief]

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