Tumor necrosis factor-α (TNF-α)

Definition:

Tumor necrosis factor-α (TNF-α)is a pro-inflammatory cytokine. TNF-α has multi-biological effects by binding to p55 receptor and p75 receptor, such as causing inflammation, apoptotic cell death, and mediate the release of variety cytokines like IL-6, IL-8 and IL-1β.

References:

[1]. Ma K, Zhang H, Baloch Z. Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review. Int J Mol Sci. 2016 May 14;17(5):733. [Content Brief]

Biomedical Dictionary

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