Tumor protein p53-inducible nuclear protein 2

Definition:

Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.

References:

[1]. Jonathan Nowak, et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell. 2009 Feb;20(3):870-81. [Content Brief]

[2]. Bernhard G Baumgartner, et al. Identification of a novel modulator of thyroid hormone receptor-mediated action. PLoS One. 2007 Nov 21;2(11):e1183. [Content Brief]

[3]. Ana Sancho, et al. DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription. PLoS One. 2012;7(3):e34034. [Content Brief]

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