Tumor protein p73

Definition:

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation.

References:

[1]. W G Kaelin Jr, et al. The emerging p53 gene family. J Natl Cancer Inst. 1999 Apr 7;91(7):594-8. [Content Brief]

[2]. T J Grob, et al. Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ. 2001 Dec;8(12):1213-23. [Content Brief]

[3]. Julia Wallmeier, et al. Mutations in TP73 cause impaired mucociliary clearance and lissencephaly. Am J Hum Genet. 2021 Jul 1;108(7):1318-1329. [Content Brief]

[4]. Nami Koida, et al. Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation. J Biol Chem. 2008 Mar 28;283(13):8555-63. [Content Brief]

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