Type-1 angiotensin II receptor

Definition:

Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.

References:

[1]. Haitao Zhang, et al. Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell. 2015 May 7;161(4):833-44. [Content Brief]

[2]. D J Bergsma, et al. Cloning and characterization of a human angiotensin II type 1 receptor. Biochem Biophys Res Commun. 1992 Mar 31;183(3):989-95. [Content Brief]

[3]. K Noda, et al. The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry. 1996 Dec 24;35(51):16435-42. [Content Brief]

[4]. Laura M Wingler, et al. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. 2019 Jan 24;176(3):479-490.e12. [Content Brief]

[5]. Haitao Zhang, et al. Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J Biol Chem. 2015 Dec 4;290(49):29127-39. [Content Brief]

[6]. Laura M Wingler, et al. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science. 2020 Feb 21;367(6480):888-892. [Content Brief]

[7]. Man Lung Yeung, et al. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell. 2021 Apr 15;184(8):2212-2228.e12. [Content Brief]

[8]. William G Barnes, et al. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem. 2005 Mar 4;280(9):8041-50. [Content Brief]

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