Type-1-insulin-like growth factor receptor (IGF-1R)

Definition:

The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular alpha subunits and two beta subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated in cancers and promotes proliferation and cell survival.

References:

[1]. Tamara Aleksic, et al. Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 2010 Aug 15;70(16):6412-9. [Content Brief]

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