2. Biology Dictionary
  3. Tyrosine-protein kinase FRK

Tyrosine-protein kinase FRK

Definition:

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

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