Tyrosine-protein kinase Srms

Definition:

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent.

References:

[1]. Raghuveera Kumar Goel, et al. Phosphoproteomics Analysis Identifies Novel Candidate Substrates of the Nonreceptor Tyrosine Kinase, S rc- r elated Kinase Lacking C-terminal Regulatory Tyrosine and N-terminal M yristoylation S ites (SRMS). Mol Cell Proteomics. 2018 May;17(5):925-947. [Content Brief]

[2]. Raghuveera K Goel, et al. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. FEBS J. 2013 Sep;280(18):4539-59. [Content Brief]

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