ZW10 interactor

Definition:

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

References:

[1]. Geert J P L Kops, et al. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 2005 Apr 11;169(1):49-60. [Content Brief]

[2]. Antonio Musio, et al. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. Gene. 2004 Apr 28;331:33-40. [Content Brief]

[3]. Y-T Lin, et al. Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. Oncogene. 2006 Nov 2;25(52):6901-14. [Content Brief]

[4]. Hongmei Wang, et al. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem. 2004 Dec 24;279(52):54590-8. [Content Brief]

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