Celecoxib-d₃ (Synonyms: SC 58635-d₃)

Name: Celecoxib-d 3
Brand: MedChemExpress
SKU: HY-14398S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-14398S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

For research use only. We do not sell to patients.

Celecoxib-d<sub>3</sub> Chemical Structure

Celecoxib-d₃ Chemical Structure

CAS No. : 544686-18-2

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Celecoxib-d₃:

Celecoxib In-stock

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Description

Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

384.39

Formula

C₁₇H₁₁D₃F₃N₃O₂S

CAS No.

544686-18-2

Unlabeled CAS

169590-42-5

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=NN(C2=CC=C(C=C2)S(N)(=O)=O)C(C3=CC=C(C=C3)C([2H])([2H])[2H])=C1)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 25 mg/mL (65.04 mM)

DMF : ≥ 25 mg/mL (65.04 mM)

DMSO : ≥ 15 mg/mL (39.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol:PBS (pH 7.2) (1:4) : ≥ 0.1 mg/mL (0.26 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6015 mL	13.0076 mL	26.0152 mL
5 mM	0.5203 mL	2.6015 mL	5.2030 mL
10 mM	0.2602 mL	1.3008 mL	2.6015 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (258 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Penning TD, et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J Med Chem. 1997 [Content Brief]

[3]. Liu DB, et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May;33(5):682-90. [Content Brief]

[4]. Suri A, et al. The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. Oncotarget. 2016 Apr 8. [Content Brief]

[5]. Hou XL, et al. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. Neural Regen Res. 2015 Nov;10(11):1836-40. [Content Brief]

[6]. Liu C, et al. Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. Sci Rep. 2018 Mar 7;8(1):4108. [Content Brief]

[7]. Pobbati AV, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10(8):3622-3635. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol / DMF	1 mM	2.6015 mL	13.0076 mL	26.0152 mL	65.0381 mL
	5 mM	0.5203 mL	2.6015 mL	5.2030 mL	13.0076 mL
	10 mM	0.2602 mL	1.3008 mL	2.6015 mL	6.5038 mL
	15 mM	0.1734 mL	0.8672 mL	1.7343 mL	4.3359 mL
	20 mM	0.1301 mL	0.6504 mL	1.3008 mL	3.2519 mL
	25 mM	0.1041 mL	0.5203 mL	1.0406 mL	2.6015 mL
	30 mM	0.0867 mL	0.4336 mL	0.8672 mL	2.1679 mL
Ethanol / DMF	40 mM	0.0650 mL	0.3252 mL	0.6504 mL	1.6260 mL
	50 mM	0.0520 mL	0.2602 mL	0.5203 mL	1.3008 mL
	60 mM	0.0434 mL	0.2168 mL	0.4336 mL	1.0840 mL

Celecoxib-d₃ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Celecoxib-d₃544686-18-2SC 58635-d₃COXCyclooxygenaseInhibitorinhibitorinhibit

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Celecoxib-d3 (Synonyms: SC 58635-d3)

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Complete Stock Solution Preparation Table

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Celecoxib-d₃ (Synonyms: SC 58635-d₃)

Other Forms of Celecoxib-d₃:

Celecoxib-d₃ Related Antibodies

Celecoxib-d₃ Related Antibodies

Celecoxib-d₃ Related Classifications