Cemadotin  (Synonyms: LU103793 free base)

Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer^[1].

K_i: 1 μM (tubulin)^[1]

Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus^[1].
Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration^[1].
Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency^[1].
Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

640.86

C₃₅H₅₆N₆O₅

159776-69-9

CC(C)[C@H](N(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC3=CC=CC=C3)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8.  [Content Brief]

  [2]. Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4.  [Content Brief]