CGP 78608 hydrochloride

Name: CGP 78608 hydrochloride
Brand: MedChemExpress
SKU: HY-107701
Rating: 4.5 (1 reviews)

Cat. No.: HY-107701 Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC₅₀ of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC₅₀ in the low nM range (26.3 nM). Anticonvulsant activity.

For research use only. We do not sell to patients.

CGP 78608 hydrochloride Chemical Structure

CAS No. : 1135278-54-4

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

NMDA Receptor

In Vitro

CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites^[2].
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

414.58

Formula

C₁₁H₁₄BrClN₃O₅P

CAS No.

1135278-54-4

Appearance

Solid

Color

White to off-white

SMILES

OP(O)([C@H](NCC1=CC(Br)=CC(NC2=O)=C1NC2=O)C)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

1 M NaOH : ≥ 50 mg/mL (120.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4121 mL	12.0604 mL	24.1208 mL
5 mM	0.4824 mL	2.4121 mL	4.8242 mL
10 mM	0.2412 mL	1.2060 mL	2.4121 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (253 KB) HNMR (217 KB) RP-HPLC (143 KB)

Handling Instructions (2659 KB)

References

[1]. Catarzi D, et al. Competitive Gly/NMDA receptor antagonists. Curr Top Med Chem. 2006;6(8):809-21. [Content Brief]

[2]. Grand T, et al. Unmasking GluN1/GluN3A excitatory glycine NMDA receptors. Nat Commun. 2018 Nov 13;9(1):4769. [Content Brief]

[3]. Hilgier W, et al. A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. Brain Res. 2004 Jul 23;1015(1-2):186-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

1 M NaOH	1 mM	2.4121 mL	12.0604 mL	24.1208 mL	60.3020 mL
	5 mM	0.4824 mL	2.4121 mL	4.8242 mL	12.0604 mL
	10 mM	0.2412 mL	1.2060 mL	2.4121 mL	6.0302 mL
	15 mM	0.1608 mL	0.8040 mL	1.6081 mL	4.0201 mL
	20 mM	0.1206 mL	0.6030 mL	1.2060 mL	3.0151 mL
	25 mM	0.0965 mL	0.4824 mL	0.9648 mL	2.4121 mL
	30 mM	0.0804 mL	0.4020 mL	0.8040 mL	2.0101 mL
	40 mM	0.0603 mL	0.3015 mL	0.6030 mL	1.5075 mL
	50 mM	0.0482 mL	0.2412 mL	0.4824 mL	1.2060 mL
	60 mM	0.0402 mL	0.2010 mL	0.4020 mL	1.0050 mL
	80 mM	0.0302 mL	0.1508 mL	0.3015 mL	0.7538 mL
	100 mM	0.0241 mL	0.1206 mL	0.2412 mL	0.6030 mL