2. Metabolic Enzyme/Protease
  3. MMP
  4. cis-ACCP

cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases.

For research use only. We do not sell to patients.

cis-ACCP Chemical Structure

cis-ACCP Chemical Structure

CAS No. : 777075-44-2

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Based on 1 publication(s) in Google Scholar

cis-ACCP Related Antibodies

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Description

cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases[1].

IC50 & Target

MMP-2

4 μM (IC50)

MMP-9

20 μM (IC50)

In Vitro

cis-ACCP can inhibit MMP-2 and MMP-9 with IC50 values of 4 μM and 20 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-ACCP Related Antibodies
In Vivo

cis-ACCP (i.p.; 50, 250, 500 mg/kg; daily for two weeks) shows no toxic effects and reduces metastasis formation in mice[1].
cis-ACCP (oral, i.v.,i.p.; 50, 150 mg/kg) only has distribution in the extracellular fluid[1].
Pharmacokinetic Parameters of cis-ACCP in rats[1].

PK parameter iv PO ip
AUC (min • µg/mL) 7637 79 2677
T1/2 (min) 18.8 126 108
Cmax(ng/mL) 306000 712 144000
CL (mL/min/kg) 6.9 - -
Tmax(min) - 17.4 0.5
Vss(mL/Kg) 186 - -
F (%) - 0.35 11.8
Fu (%) 83.9 2.2 48
Ttime over MIC (hr) >4 >6 24

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL mice[1]
Dosage: 50, 250, 500 mg/kg; 12.5 to 50 mg/kg
Administration: Oral, intraperitoneal, daily for two weeks; daily, 21 days
Result: Showed no toxic effects and showed 50-85% inhibition of metastasis formation, depending on the dose.
Animal Model: Rats[1]
Dosage: 50, 150 mg/kg
Administration: Oral, intravenous, intraperitoneal
Result: Showed 84% of the intravenously administered drug are excreted unchanged.
Molecular Weight

222.18

Formula

C7H15N2O4P
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

OP(O)(C(N[C@H]1[C@@H](N)CCCC1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (112.52 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5009 mL 22.5043 mL 45.0086 mL
5 mM 0.9002 mL 4.5009 mL 9.0017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5009 mL 22.5043 mL 45.0086 mL 112.5214 mL
5 mM 0.9002 mL 4.5009 mL 9.0017 mL 22.5043 mL
10 mM 0.4501 mL 2.2504 mL 4.5009 mL 11.2521 mL
15 mM 0.3001 mL 1.5003 mL 3.0006 mL 7.5014 mL
20 mM 0.2250 mL 1.1252 mL 2.2504 mL 5.6261 mL
25 mM 0.1800 mL 0.9002 mL 1.8003 mL 4.5009 mL
30 mM 0.1500 mL 0.7501 mL 1.5003 mL 3.7507 mL
40 mM 0.1125 mL 0.5626 mL 1.1252 mL 2.8130 mL
50 mM 0.0900 mL 0.4501 mL 0.9002 mL 2.2504 mL
60 mM 0.0750 mL 0.3751 mL 0.7501 mL 1.8754 mL
80 mM 0.0563 mL 0.2813 mL 0.5626 mL 1.4065 mL
100 mM 0.0450 mL 0.2250 mL 0.4501 mL 1.1252 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cis-ACCP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-ACCP777075-44-2MMPMatrix metalloproteinasesoralmatrix metalloproteinases (MMPs)MMP-2MMP-9chronic diseasesInhibitorinhibitorinhibit

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