µ-Conotoxin-CnIIIC 

μ-Conotoxin-CnIIIC is a 22-residue conopeptide that can be isolated from Conus consors. μ-Conotoxin-CnIIIC is a potent and persistent blocker of Na_V1.4 channel. μ-Conotoxin-CnIIIC has analgesic, anaesthetic and myorelaxant properties^[1][2].

NaV1.4 Channel^[2]

2375.70

C₉₂H₁₃₉N₃₅O₂₈S₆

936616-33-0

{Glp}-Gly-Cys-Cys-Asn-Gly-Pro-Lys-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)

{Glp}-GCCNGPKGCSSKWCRDHARCC-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)

[C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@]4(C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC5=CN=CN5)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@]6(CSSC[C@](NC(=O)[C@@H](NC(CNC(=O)[C@@H]7CCC(=O)N7)=O)CSSC4)(C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N8[C@](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N3)(CSSC[C@@H](C(N)=O)NC6=O)[H])(CCC8)[H])[H])[H])[H]]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Markgraf R, et al. Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Br J Pharmacol. 2012 Oct;167(3):576-86.  [Content Brief]

  [2]. Del Río-Sancho S, et al. Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant properties. Int J Pharm. 2017 Feb 25;518(1-2):59-65.  [Content Brief]