1. Others Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite
  3. Cortisone-d2

Cortisone-d2  (Synonyms: 17-Hydroxy-11-dehydrocorticosterone-d2; Kendall's compound E-d2)

Cat. No.: HY-17461S3
Handling Instructions

Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

For research use only. We do not sell to patients.

Cortisone-d<sub>2</sub> Chemical Structure

Cortisone-d2 Chemical Structure

CAS No. : 2687960-86-5

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Description

Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

362.46

Formula

C21H26D2O5

CAS No.
Unlabeled CAS

53-06-5

SMILES

C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C([2H])C([2H])[C@]4(C)[C@@]3([H])C2=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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