Cymarin

Cat. No.: HY-111934: FAQs
Data Sheet SDS COA Handling Instructions

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Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant.

For research use only. We do not sell to patients.

Cymarin Chemical Structure

CAS No. : 508-77-0

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Biological Activity
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Description

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K⁺ release (IC₅₀=0.42 μM)^[1]. Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer^[2]^[4]. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant^[3].

In Vitro

Cymarin (0.25-1 μM) inhibites PAX6 expression by blocking IRES-directed translation and inhibits 47.8% proliferation of MCF-7 cells with the concentration of 1 μM ^[2].
Cymarin downregulates UGT1A10 expression, eliminates TRA-1-60 (IC₅₀ of 15.2 nM) and TRA-1-81 cells (IC₅₀ of 5.1 nM) in cell lines SW1990GR, inhibits proliferations and cell viabilities of pancreatic cancer cells SW1990 and SW1990GR (IC₅₀ of 33.8 nM for SW1990 and 40.8 for SW1990GR).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	MCF-7
Concentration:	0.25-1 μM
Incubation Time:	24 h
Result:	Downregulated levels of PAX6.

Cell Proliferation Assay^[2]

Cell Line:	MCF-7
Concentration:	0.25-1 μM
Incubation Time:	5 days
Result:	Inhibits proliferation of MCF-7 cells in a dose-dependent manner.

Real Time qPCR^[4]

Cell Line:	SW1990 and SW1990GR
Concentration:	7-15 μM
Incubation Time:
Result:	Decreased levels of UGT1A10 transcription.

Cell Viability Assay^[4]

Cell Line:	SW1990 and SW1990GR
Concentration:	0-500 nM
Incubation Time:	72 h
Result:	Decreased cell viability with IC₅₀ of 33.8 nM for SW1990 and 40.8 for SW1990GR.

In Vivo

Cymarin inhibits growth of neonate Trichoplusia ni larvae with EC₅₀ of 157 p.p.m, reveals an antifeedant effect against Trichoplusia ni larva with a DC₅₀ of 10.8 μg/cm²^[3].
Cymarin (2 mg/kg, i.p., twice a week for 3 weeks) inhibits tumor growth, eliminates TRA-1-60 cells and decreases chemoresistance in SW1990 xenografted nude mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Trichoplusia ni^[3]
Dosage:	1000 p.p.m.
Administration:	p.o. for 10 days
Result:	Inhibited growth and revealed a feeding deterrent to T.ni.

Animal Model:	Luciferase labeled SW1990 xenograft in nude mice^[4]
Dosage:	2 mg/kg
Administration:	i.p., twice a week for 3 weeks
Result:	Inhibited tumor growth.

Molecular Weight

548.66

Formula

C₃₀H₄₄O₉

CAS No.

508-77-0

Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 97.82%

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Data Sheet (280 KB) SDS (644 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480. [Content Brief]

[2]. Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98(4):161-169. [Content Brief]

[3]. Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.

[4]. Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039. [Content Brief]

Cymarin Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cymarin508-77-0Parasitepancreatic cancerbreast cancerantifeedantMCF-7SW1990Trichoplusia niInhibitorinhibitorinhibit

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