2. Metabolic Enzyme/Protease
  3. Ceramidase
  4. D-erythro-MAPP

D-erythro-MAPP  (Synonyms: D-e-MAPP)

Cat. No.: HY-137422 Purity: ≥98.0%
COA Handling Instructions

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D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro.

For research use only. We do not sell to patients.

D-erythro-MAPP Chemical Structure

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

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5 mg USD 250 In-stock
10 mg USD 425 In-stock
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Based on 1 publication(s) in Google Scholar

D-erythro-MAPP Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE D-erythro-MAPP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

In Vitro

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-erythro-MAPP Related Antibodies

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.
Molecular Weight

361.56

Formula

C23H39NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC(CCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (55.32 mM)

Ethanol : ≥ 20 mg/mL (55.32 mM)

DMSO : ≥ 1 mg/mL (2.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7658 mL 13.8290 mL 27.6579 mL
5 mM 0.5532 mL 2.7658 mL 5.5316 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF / Ethanol 1 mM 2.7658 mL 13.8290 mL 27.6579 mL 69.1448 mL
DMF / Ethanol 5 mM 0.5532 mL 2.7658 mL 5.5316 mL 13.8290 mL
10 mM 0.2766 mL 1.3829 mL 2.7658 mL 6.9145 mL
15 mM 0.1844 mL 0.9219 mL 1.8439 mL 4.6097 mL
20 mM 0.1383 mL 0.6914 mL 1.3829 mL 3.4572 mL
25 mM 0.1106 mL 0.5532 mL 1.1063 mL 2.7658 mL
30 mM 0.0922 mL 0.4610 mL 0.9219 mL 2.3048 mL
40 mM 0.0691 mL 0.3457 mL 0.6914 mL 1.7286 mL
50 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3829 mL
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D-erythro-MAPP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-erythro-MAPP143492-38-0D-e-MAPPCeramidaseG0G1arrestMCF-7cellcycleInhibitorinhibitorinhibit

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