D-JBD19 

D-JBD19 is a non-permeable peptide^[1]. D-JBD19 has neuroprotective effects^[2].

D-JBD19 is a non-permeable cargo corresponding to dJNKi peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective effects of D-JBD19 against middle cerebral artery occlusion (MCAO) as compared with D-JNKI1. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2250.56

C₉₉H₁₆₄N₃₂O₂₈

954134-42-0

Solid

White to off-white

Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg

DQSRPVQPFLNLTTPRKPR

N=C(N)NCCC[C@H](C(O)=O)NC([C@@H]1N(C([C@@H](CCCCN)NC([C@@H](CCCNC(N)=N)NC([C@@H]2N(C([C@@H]([C@@H](O)C)NC([C@@H]([C@@H](O)C)NC([C@@H](CC(C)C)NC([C@@H](CC(N)=O)NC([C@@H](CC(C)C)NC([C@@H](CC3=CC=CC=C3)NC([C@@H]4N(C([C@@H](CCC(N)=O)NC([C@@H](C(C)C)NC([C@@H]5N(C([C@@H](CCCNC(N)=N)NC([C@@H](CO)NC([C@@H](CCC(N)=O)NC([C@@H](CC(O)=O)N)=O)=O)=O)=O)CCC5)=O)=O)=O)CCC4)=O)=O)=O)=O)=O)=O)=O)CCC2)=O)=O)=O)CCC1)=O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34.  [Content Brief]

  [2]. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52.  [Content Brief]