[D-Phe2,6, Pro3]-LH-RH

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[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist.

For research use only. We do not sell to patients.

[D-Phe2,6, Pro3]-LH-RH Chemical Structure

CAS No. : 64789-67-9

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Description

[D-Phe2,6, Pro3]-LH-RH is a potent luteinizing hormone releasing hormone (LHRH) antagonist^[1].

In Vitro

[D-Phe2,6, Pro3]-LH-RH (0.1 pM-1 mM; 24 h) does not alter GnRH binding capacity in pituitary cells but blocks the increase in sites induced by GnRH^[2].
[D-Phe2,6, Pro3]-LH-RH (2.7 μM) causes significant increases in thyrotropin (TSH) secretion in pituitaries^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[D-Phe2,6, Pro3]-LH-RH (300 mg/monkey, SC, 50 mg/injection; six injections) inhibits spontaneous preovulatory gonadotropin surges and prevents ovulation in the rhesus monkey^[1].
[D-Phe2,6, Pro3]-LH-RH (750 μg, single injection at 12:00 h on the day of proestrus) inhibits ovulation in 100% of treated rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult rhesus monkeys^[1]
Dosage:	300 mg/monkey
Administration:	SC, every 8 h at a dose of 50 mg/injection; six injections
Result:	Showed antagonistic activity: 1) an immediate cessation of the LU and FSH surges; 2) prolonged surges and/or abnormal, discontinuous gonadotropin secretion; 3) LH and FSH peaks of diminished magnitude; 4) the absence of concomitant LH and FSH midcycle peaks; 3) LH and FSH peaks of diminished magnitude; 4) the absence of concomitant LH and FSH midcycle peaks; 5) suppression of serum estradiol concentrations without concurrent reductions in serum gonadotropin values; or 6) a failure to identify corpora lutea at the time of laparoscopic visualization of the ovaries.

Molecular Weight

1193.35

Formula

C₅₉H₈₀N₁₄O₁₃

CAS No.

64789-67-9

Unlabeled CAS

Sequence Shortening

{Glp}-{d-Phe}-PSY-{d-Phe}-LRPG-NH2

SMILES

O=C(N[C@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6)NC6=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wilks JW, et al. Effect of [D-Phe2, Pro3, D-Phe6]-luteinizing hormone releasing hormone, an antagonist, on preovulatory gonadotropin secretion in the rhesus monkey. Biol Reprod. 1980 Aug;23(1):1-9. [Content Brief]

[2]. Loumaye E, et al. Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells. Science. 1982 Feb 19;215(4535):983-5. [Content Brief]

[3]. Gian, et al. TRH, LHRH and Synthetic [D-Phe2-6, Pro3]-LHRH Stimulate in Vitro Thyrotropin Secretion by Crested Newt Pituitaries. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY: FROM MOLECULAR TO INTEGRATIVE BIOLOGY. 1998;839(1):522-523.

[D-Phe2,6, Pro3]-LH-RH Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Phe2,6, Pro3]-LH-RH64789-67-9GnRH ReceptorGonadotropin releasing hormone receptorGNRHRLHFSHLHRHantiovulatorygonadotropinovulationInhibitorinhibitorinhibit

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