2. Anti-infection
  3. Bacterial
  4. D13-9001

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively. D13-9001 exhibits antibiotic activities.

For research use only. We do not sell to patients.

D13-9001 Chemical Structure

D13-9001 Chemical Structure

CAS No. : 957471-96-4

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Based on 1 publication(s) in Google Scholar

D13-9001 Related Antibodies

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Description

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].

IC50 & Target

KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1]
In Vitro

D13-9001 exhibits high solubility and a good safety profile[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D13-9001 Related Antibodies
In Vivo

D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3]
Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg
Administration: Intravenous drip infusion; 2 hours
Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone.
Molecular Weight

693.78

Formula

C31H39N11O6S
CAS No.
Unlabeled Cas

SMILES

O=C(NCC[N+](C)(CC([O-])=O)C)O[C@H]1CN(C(N=C2N3C=CC(C(NC4=NC(C(C)(C)C)=CS4)=O)=C2)=C(/C=C/C5=NN=NN5)C3=O)CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D13-9001 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D13-9001957471-96-4BacterialInhibitorinhibitorinhibit

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