DCG-IV 

DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects^[1][2].

DCG-IV is also an NMDA receptor agonist in the rat cortical slice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

203.15

C₇H₉NO₆

147782-19-2

Solid

White to off-white

O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O

Room temperature in continental US; may vary elsewhere.

• [1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51.  [Content Brief]

  [2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83.  [Content Brief]

  [3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30.  [Content Brief]

  [4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91.  [Content Brief]