Delequamine  (Synonyms: RS-15385-197)

Delequamine (RS-15385-197) is an orally active and selective α₂-adrenergic receptor antagonist. Delequamine can increase the sexual behavior score of both male and female rats and can be used in the research of sexual dysfunction^[1].

Delequamine (0.4-6.4 mg/kg; oral, single dose) can increase the sexual behavior score in a dose-dependent manner in a model where untrained male rats are exposed to estrogen-progesterone-treated, sexually receptive female rats. Furthermore, the combination of Delequamine (0.4 mg/kg; oral, single dose) and 8-OH-DPAT (HY-112061) (0.1 mg/kg; subcutaneous injection) can increase the percentage of mounts, intromissions, and ejaculations in rats, shorten the ejaculation latency, and reduce the number of intromissions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

350.48

C₁₈H₂₆N₂O₃S

119905-05-4

CS(=O)(N1[C@@]2([H])C[C@@]3([H])C4=CC=C(OC)C=C4CCN3C[C@@]2([H])CCC1)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tallentire D, et al. Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996;118(1):63-72.  [Content Brief]