2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Autophagy Anti-infection
  3. Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic
  4. Dexamethasone-d5

Dexamethasone-d5  (Synonyms: Hexadecadrol-d5; Prednisolone F-d5)

Cat. No.: HY-14648S Purity: 99.86%
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Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

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Dexamethasone-d<sub>5</sub> Chemical Structure

Dexamethasone-d5 Chemical Structure

CAS No. : 358731-91-6

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Based on 1 publication(s) in Google Scholar

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Dexamethasone-d5 Related Antibodies

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Description

Dexamethasone-d5 is the deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dexamethasone-d5 Related Antibodies
Molecular Weight

397.49

Formula

C22H24D5FO5
CAS No.
Unlabeled CAS

50-02-2
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@]12[C@](C(C([2H])(O)[2H])=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])CC([2H])([2H])C4=C([2H])C(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (628.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5158 mL 12.5789 mL 25.1579 mL
5 mM 0.5032 mL 2.5158 mL 5.0316 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5158 mL 12.5789 mL 25.1579 mL 62.8947 mL
5 mM 0.5032 mL 2.5158 mL 5.0316 mL 12.5789 mL
10 mM 0.2516 mL 1.2579 mL 2.5158 mL 6.2895 mL
15 mM 0.1677 mL 0.8386 mL 1.6772 mL 4.1930 mL
20 mM 0.1258 mL 0.6289 mL 1.2579 mL 3.1447 mL
25 mM 0.1006 mL 0.5032 mL 1.0063 mL 2.5158 mL
30 mM 0.0839 mL 0.4193 mL 0.8386 mL 2.0965 mL
40 mM 0.0629 mL 0.3145 mL 0.6289 mL 1.5724 mL
50 mM 0.0503 mL 0.2516 mL 0.5032 mL 1.2579 mL
60 mM 0.0419 mL 0.2096 mL 0.4193 mL 1.0482 mL
80 mM 0.0314 mL 0.1572 mL 0.3145 mL 0.7862 mL
100 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.6289 mL
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Dexamethasone-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dexamethasone-d5358731-91-6Hexadecadrol-d5Prednisolone F-d5Glucocorticoid ReceptorSARS-CoVAutophagyComplement SystemMitophagyBacterialAntibioticSARS coronavirusMitochondrial AutophagyInhibitorinhibitorinhibit

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