DL-Pyroglutamic acid-d₅

Name: DL-Pyroglutamic acid-d 5
Brand: MedChemExpress
SKU: HY-W012738S
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012738S: FAQs
Data Sheet Handling Instructions

Molarity Calculator

DL-Pyroglutamic acid-d₅ is the deuterium labeled DL-Pyroglutamic acid[1].

For research use only. We do not sell to patients.

DL-Pyroglutamic acid-d<sub>5</sub> Chemical Structure

DL-Pyroglutamic acid-d₅ Chemical Structure

CAS No. : 352431-30-2

Size	Price	Stock	Quantity
1 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DL-Pyroglutamic acid-d₅:

DL-Pyroglutamic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-Pyroglutamic acid-d₅ is the deuterium labeled DL-Pyroglutamic acid[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

134.14

Formula

C₅H₂D₅NO₃

CAS No.

352431-30-2

Unlabeled CAS

149-87-1

Appearance

Lyophilized Powder

Color

White to off-white

SMILES

OC(C1([2H])NC(C([2H])([2H])C1([2H])[2H])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (745.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4549 mL	37.2745 mL	74.5490 mL
5 mM	1.4910 mL	7.4549 mL	14.9098 mL
10 mM	0.7455 mL	3.7274 mL	7.4549 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.4549 mL	37.2745 mL	74.5490 mL	186.3724 mL
	5 mM	1.4910 mL	7.4549 mL	14.9098 mL	37.2745 mL
	10 mM	0.7455 mL	3.7274 mL	7.4549 mL	18.6372 mL
	15 mM	0.4970 mL	2.4850 mL	4.9699 mL	12.4248 mL
	20 mM	0.3727 mL	1.8637 mL	3.7274 mL	9.3186 mL
	25 mM	0.2982 mL	1.4910 mL	2.9820 mL	7.4549 mL
	30 mM	0.2485 mL	1.2425 mL	2.4850 mL	6.2124 mL
	40 mM	0.1864 mL	0.9319 mL	1.8637 mL	4.6593 mL
	50 mM	0.1491 mL	0.7455 mL	1.4910 mL	3.7274 mL
	60 mM	0.1242 mL	0.6212 mL	1.2425 mL	3.1062 mL
	80 mM	0.0932 mL	0.4659 mL	0.9319 mL	2.3297 mL
	100 mM	0.0745 mL	0.3727 mL	0.7455 mL	1.8637 mL